Multicenter linkage study of schizophrenia loci on chromosome 22q
Identifieur interne : 00AB83 ( Main/Exploration ); précédent : 00AB82; suivant : 00AB84Multicenter linkage study of schizophrenia loci on chromosome 22q
Auteurs : B. J. Mowry [Australie] ; P. A. Holmans [Royaume-Uni] ; A. E. Pulver [États-Unis] ; P. V. Gejman [États-Unis] ; B. Riley [États-Unis] ; N. M. Williams [Royaume-Uni] ; C. Laurent [France] ; S. G. Schwab [Allemagne] ; D. B. Wildenauer [Allemagne] ; S. Bauche [France] ; M. J. Owen [Royaume-Uni] ; B. Wormley [États-Unis] ; A. R. Sanders [États-Unis] ; G. Nestadt [États-Unis] ; K. Y. Liang [États-Unis] ; J. Duan [États-Unis] ; R. Ribble [États-Unis] ; N. Norton [Royaume-Uni] ; S. Soubigou [France] ; W. Maier [Allemagne] ; K. R. Ewen-White [Australie] ; N. Demarchi [Italie] ; B. Carpenter [États-Unis] ; D. Walsh [Irlande (pays)] ; H. Williams [Royaume-Uni] ; M. Jay [France] ; M. Albus [Allemagne] ; D. A. Nertney [Australie] ; G. Papadimitriou [Grèce] ; A. O'Neill [Royaume-Uni] ; M. C. O'Donovan [Royaume-Uni] ; J.-F. Deleuze [France] ; F. B. Lerer [Israël] ; D. Dikeos [Grèce] ; K. S. Kendler [États-Unis] ; J. Mallet [France] ; J. M. Silverman [États-Unis] ; R. R. Crowe [États-Unis] ; D. F. Levinson [États-Unis]Source :
- Molecular psychiatry [ 1359-4184 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkaae analvsis even in larae samples.
Affiliations:
- Allemagne, Australie, France, Grèce, Irlande (pays), Israël, Italie, Royaume-Uni, États-Unis
- Attique (région), District de Cologne, Rhénanie-du-Nord-Westphalie, Île-de-France
- Athènes, Bonn, Paris, Évry (Essonne)
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Holmans</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>MRC Biostatistics Unit</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>MRC Biostatistics Unit</wicri:noRegion></affiliation></author><author><name sortKey="Pulver, A E" sort="Pulver, A E" uniqKey="Pulver A" first="A. E." last="Pulver">A. E. Pulver</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Gejman, P V" sort="Gejman, P V" uniqKey="Gejman P" first="P. V." last="Gejman">P. V. 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Williams</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C." last="Laurent">C. 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Schwab</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Bauche, S" sort="Bauche, S" uniqKey="Bauche S" first="S." last="Bauche">S. Bauche</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Wormley, B" sort="Wormley, B" uniqKey="Wormley B" first="B." last="Wormley">B. Wormley</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Nestadt, G" sort="Nestadt, G" uniqKey="Nestadt G" first="G." last="Nestadt">G. Nestadt</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Liang, K Y" sort="Liang, K Y" uniqKey="Liang K" first="K. Y." last="Liang">K. Y. Liang</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J." last="Duan">J. Duan</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Ribble, R" sort="Ribble, R" uniqKey="Ribble R" first="R." last="Ribble">R. Ribble</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Soubigou, S" sort="Soubigou, S" uniqKey="Soubigou S" first="S." last="Soubigou">S. Soubigou</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Aventis Pharma SA</s1><s2>Evry</s2><s3>FRA</s3><sZ>19 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Ewen White, K R" sort="Ewen White, K R" uniqKey="Ewen White K" first="K. R." last="Ewen-White">K. R. Ewen-White</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Australian Genome Research Facility, Walter and Eliza Hall Institute of Medical Research</s1><s2>Parkville, Victoria</s2><s3>AUS</s3><sZ>21 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Parkville, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Demarchi, N" sort="Demarchi, N" uniqKey="Demarchi N" first="N." last="Demarchi">N. Demarchi</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Clinica Psichiatrica, Seconda Universita degli Studi di Napoli</s1><s2>Naples</s2><s3>ITA</s3><sZ>22 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Carpenter, B" sort="Carpenter, B" uniqKey="Carpenter B" first="B." last="Carpenter">B. Carpenter</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>The Health Research Board</s1><s2>Dublin</s2><s3>IRL</s3><sZ>24 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>The Health Research Board</wicri:noRegion></affiliation></author><author><name sortKey="Williams, H" sort="Williams, H" uniqKey="Williams H" first="H." last="Williams">H. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jay, M" sort="Jay, M" uniqKey="Jay M" first="M." last="Jay">M. Jay</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>State Mental Hospital</s1><s2>Haar</s2><s3>DEU</s3><sZ>27 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Haar</wicri:noRegion><wicri:noRegion>State Mental Hospital</wicri:noRegion><wicri:noRegion>State Mental Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Nertney, D A" sort="Nertney, D A" uniqKey="Nertney D" first="D. A." last="Nertney">D. A. Nertney</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Centre for Mental Health Research, The Park - Centre for Mental Health</s1><s2>Wacol, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Papadimitriou, G" sort="Papadimitriou, G" uniqKey="Papadimitriou G" first="G." last="Papadimitriou">G. Papadimitriou</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="O Neill, A" sort="O Neill, A" uniqKey="O Neill A" first="A." last="O'Neill">A. O'Neill</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Psychiatry, Queens University</s1><s2>Belfast</s2><s3>GBR</s3><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Aventis Pharma SA</s1><s2>Evry</s2><s3>FRA</s3><sZ>19 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Lerer, F B" sort="Lerer, F B" uniqKey="Lerer F" first="F. B." last="Lerer">F. B. Lerer</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1><s2>Jerusalem</s2><s3>ISR</s3><sZ>33 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Dikeos, D" sort="Dikeos, D" uniqKey="Dikeos D" first="D." last="Dikeos">D. Dikeos</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Silverman, J M" sort="Silverman, J M" uniqKey="Silverman J" first="J. M." last="Silverman">J. M. Silverman</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Psychiatry, Mt Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Crowe, R R" sort="Crowe, R R" uniqKey="Crowe R" first="R. R." last="Crowe">R. R. Crowe</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Mental Health Clinical Research Center and Department of Psychiatry, The University of Iowa College of Medicine</s1><s2>Iowa City, IW</s2><s3>USA</s3><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City, IW</wicri:noRegion></affiliation></author><author><name sortKey="Levinson, D F" sort="Levinson, D F" uniqKey="Levinson D" first="D. F." last="Levinson">D. F. Levinson</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0482945</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0482945 INIST</idno><idno type="RBID">Pascal:04-0482945</idno><idno type="wicri:Area/PascalFrancis/Corpus">004D09</idno><idno type="wicri:Area/PascalFrancis/Curation">001405</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">004A47</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">004A47</idno><idno type="wicri:doubleKey">1359-4184:2004:Mowry B:multicenter:linkage:study</idno><idno type="wicri:Area/Main/Merge">00B874</idno><idno type="wicri:Area/Main/Curation">00AB83</idno><idno type="wicri:Area/Main/Exploration">00AB83</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Multicenter linkage study of schizophrenia loci on chromosome 22q</title><author><name sortKey="Mowry, B J" sort="Mowry, B J" uniqKey="Mowry B" first="B. J." last="Mowry">B. J. Mowry</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Centre for Mental Health Research, The Park - Centre for Mental Health</s1><s2>Wacol, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol, Queensland</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Psychiatry, University of Queensland</s1><s2>Brisbane, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Brisbane, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Holmans, P A" sort="Holmans, P A" uniqKey="Holmans P" first="P. A." last="Holmans">P. A. Holmans</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>MRC Biostatistics Unit</s1><s2>Cambridge</s2><s3>GBR</s3><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>MRC Biostatistics Unit</wicri:noRegion></affiliation></author><author><name sortKey="Pulver, A E" sort="Pulver, A E" uniqKey="Pulver A" first="A. E." last="Pulver">A. E. Pulver</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Gejman, P V" sort="Gejman, P V" uniqKey="Gejman P" first="P. V." last="Gejman">P. V. Gejman</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Riley, B" sort="Riley, B" uniqKey="Riley B" first="B." last="Riley">B. Riley</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N. M." last="Williams">N. M. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C." last="Laurent">C. Laurent</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Bauche, S" sort="Bauche, S" uniqKey="Bauche S" first="S." last="Bauche">S. Bauche</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Wormley, B" sort="Wormley, B" uniqKey="Wormley B" first="B." last="Wormley">B. Wormley</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Nestadt, G" sort="Nestadt, G" uniqKey="Nestadt G" first="G." last="Nestadt">G. Nestadt</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Psychiatry, Johns Hopkins University School of Medicine</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Liang, K Y" sort="Liang, K Y" uniqKey="Liang K" first="K. Y." last="Liang">K. Y. Liang</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health</s1><s2>Baltimore, MD</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Baltimore, MD</wicri:noRegion></affiliation></author><author><name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J." last="Duan">J. Duan</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Ribble, R" sort="Ribble, R" uniqKey="Ribble R" first="R." last="Ribble">R. Ribble</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Soubigou, S" sort="Soubigou, S" uniqKey="Soubigou S" first="S." last="Soubigou">S. Soubigou</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Aventis Pharma SA</s1><s2>Evry</s2><s3>FRA</s3><sZ>19 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Psychiatry, University of Bonn</s1><s2>Bonn</s2><s3>DEU</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Ewen White, K R" sort="Ewen White, K R" uniqKey="Ewen White K" first="K. R." last="Ewen-White">K. R. Ewen-White</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Australian Genome Research Facility, Walter and Eliza Hall Institute of Medical Research</s1><s2>Parkville, Victoria</s2><s3>AUS</s3><sZ>21 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Parkville, Victoria</wicri:noRegion></affiliation></author><author><name sortKey="Demarchi, N" sort="Demarchi, N" uniqKey="Demarchi N" first="N." last="Demarchi">N. Demarchi</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Clinica Psichiatrica, Seconda Universita degli Studi di Napoli</s1><s2>Naples</s2><s3>ITA</s3><sZ>22 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Carpenter, B" sort="Carpenter, B" uniqKey="Carpenter B" first="B." last="Carpenter">B. Carpenter</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>North western University, ENH Research Institute</s1><s2>Evanston, IL</s2><s3>USA</s3><sZ>4 aut.</sZ><sZ>13 aut.</sZ><sZ>16 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Evanston, IL</wicri:noRegion></affiliation></author><author><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>The Health Research Board</s1><s2>Dublin</s2><s3>IRL</s3><sZ>24 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>The Health Research Board</wicri:noRegion></affiliation></author><author><name sortKey="Williams, H" sort="Williams, H" uniqKey="Williams H" first="H." last="Williams">H. Williams</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Jay, M" sort="Jay, M" uniqKey="Jay M" first="M." last="Jay">M. Jay</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>State Mental Hospital</s1><s2>Haar</s2><s3>DEU</s3><sZ>27 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Haar</wicri:noRegion><wicri:noRegion>State Mental Hospital</wicri:noRegion><wicri:noRegion>State Mental Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Nertney, D A" sort="Nertney, D A" uniqKey="Nertney D" first="D. A." last="Nertney">D. A. Nertney</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Queensland Centre for Mental Health Research, The Park - Centre for Mental Health</s1><s2>Wacol, Queensland</s2><s3>AUS</s3><sZ>1 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Wacol, Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Papadimitriou, G" sort="Papadimitriou, G" uniqKey="Papadimitriou G" first="G." last="Papadimitriou">G. Papadimitriou</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="O Neill, A" sort="O Neill, A" uniqKey="O Neill A" first="A." last="O'Neill">A. O'Neill</name><affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Department of Psychiatry, Queens University</s1><s2>Belfast</s2><s3>GBR</s3><sZ>30 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Psychological Medicine, University of Wales College of Medicine</s1><s2>Cardiff</s2><s3>GBR</s3><sZ>6 aut.</sZ><sZ>11 aut.</sZ><sZ>18 aut.</sZ><sZ>25 aut.</sZ><sZ>31 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Aventis Pharma SA</s1><s2>Evry</s2><s3>FRA</s3><sZ>19 aut.</sZ><sZ>32 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Évry (Essonne)</settlement></placeName></affiliation></author><author><name sortKey="Lerer, F B" sort="Lerer, F B" uniqKey="Lerer F" first="F. B." last="Lerer">F. B. Lerer</name><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Department of Psychiatry, Hadassah-Hebrew University Medical Center</s1><s2>Jerusalem</s2><s3>ISR</s3><sZ>33 aut.</sZ></inist:fA14><country>Israël</country><wicri:noRegion>Jerusalem</wicri:noRegion></affiliation></author><author><name sortKey="Dikeos, D" sort="Dikeos, D" uniqKey="Dikeos D" first="D." last="Dikeos">D. Dikeos</name><affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Psychiatry, University of Athens Medical School</s1><s2>Athens</s2><s3>GRC</s3><sZ>29 aut.</sZ><sZ>34 aut.</sZ></inist:fA14><country>Grèce</country><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University</s1><s2>Richmond, VA</s2><s3>USA</s3><sZ>5 aut.</sZ><sZ>12 aut.</sZ><sZ>13 aut.</sZ><sZ>17 aut.</sZ><sZ>35 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Richmond, VA</wicri:noRegion></affiliation></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, Centre National de la Recherche Scientifique, Hôpital de la Pitié Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>10 aut.</sZ><sZ>26 aut.</sZ><sZ>36 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Silverman, J M" sort="Silverman, J M" uniqKey="Silverman J" first="J. M." last="Silverman">J. M. Silverman</name><affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Department of Psychiatry, Mt Sinai School of Medicine</s1><s2>New York, NY</s2><s3>USA</s3><sZ>37 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Crowe, R R" sort="Crowe, R R" uniqKey="Crowe R" first="R. R." last="Crowe">R. R. Crowe</name><affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Mental Health Clinical Research Center and Department of Psychiatry, The University of Iowa College of Medicine</s1><s2>Iowa City, IW</s2><s3>USA</s3><sZ>38 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Iowa City, IW</wicri:noRegion></affiliation></author><author><name sortKey="Levinson, D F" sort="Levinson, D F" uniqKey="Levinson D" first="D. F." last="Levinson">D. F. Levinson</name><affiliation wicri:level="1"><inist:fA14 i1="21"><s1>Department of Psychiatry, University of Pennsylvania</s1><s2>Philadelphia, PA</s2><s3>USA</s3><sZ>39 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia, PA</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Molecular psychiatry</title><title level="j" type="abbreviated">Mol. psychiatry</title><idno type="ISSN">1359-4184</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Molecular psychiatry</title><title level="j" type="abbreviated">Mol. psychiatry</title><idno type="ISSN">1359-4184</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term><term>Candidate gene</term><term>Deletion</term><term>Genetic linkage</term><term>Genetic marker</term><term>Human</term><term>Microsatellite DNA</term><term>Multicenter study</term><term>Schizophrenia</term><term>Sexual dimorphism</term><term>Velocardiofacial syndrome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Schizophrénie</term><term>Etude multicentrique</term><term>Liaison génétique</term><term>DNA microsatellite</term><term>Délétion</term><term>Vélocardiofacial syndrome</term><term>Gène candidat</term><term>Homme</term><term>Age apparition</term><term>Marqueur génétique</term><term>Dimorphisme sexuel</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The hypothesis of the existence of one or more schizophrenia susceptibility loci on chromosome 22q is supported by reports of genetic linkage and association, meta-analyses of linkage, and the observation of elevated risk for psychosis in people with velocardiofacial syndrome, caused by 22q11 microdeletions. We tested this hypothesis by evaluating 10 microsatellite markers spanning 22q in a multicenter sample of 779 pedigrees. We also incorporated age at onset and sex into the analysis as covariates. No significant evidence for linkage to schizophrenia or for linkage associated with earlier age at onset, gender, or heterogeneity across sites was observed. We interpret these findings to mean that the population-wide effects of putative 22q schizophrenia susceptibility loci are too weak to detect with linkaae analvsis even in larae samples.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Grèce</li><li>Irlande (pays)</li><li>Israël</li><li>Italie</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Attique (région)</li><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Bonn</li><li>Paris</li><li>Évry (Essonne)</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Mowry, B J" sort="Mowry, B J" uniqKey="Mowry B" first="B. J." last="Mowry">B. J. Mowry</name></noRegion><name sortKey="Ewen White, K R" sort="Ewen White, K R" uniqKey="Ewen White K" first="K. R." last="Ewen-White">K. R. Ewen-White</name><name sortKey="Mowry, B J" sort="Mowry, B J" uniqKey="Mowry B" first="B. J." last="Mowry">B. J. Mowry</name><name sortKey="Nertney, D A" sort="Nertney, D A" uniqKey="Nertney D" first="D. A." last="Nertney">D. A. Nertney</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Holmans, P A" sort="Holmans, P A" uniqKey="Holmans P" first="P. A." last="Holmans">P. A. Holmans</name></noRegion><name sortKey="Norton, N" sort="Norton, N" uniqKey="Norton N" first="N." last="Norton">N. Norton</name><name sortKey="O Donovan, M C" sort="O Donovan, M C" uniqKey="O Donovan M" first="M. C." last="O'Donovan">M. C. O'Donovan</name><name sortKey="O Neill, A" sort="O Neill, A" uniqKey="O Neill A" first="A." last="O'Neill">A. O'Neill</name><name sortKey="Owen, M J" sort="Owen, M J" uniqKey="Owen M" first="M. J." last="Owen">M. J. Owen</name><name sortKey="Williams, H" sort="Williams, H" uniqKey="Williams H" first="H." last="Williams">H. Williams</name><name sortKey="Williams, N M" sort="Williams, N M" uniqKey="Williams N" first="N. M." last="Williams">N. M. Williams</name></country><country name="États-Unis"><noRegion><name sortKey="Pulver, A E" sort="Pulver, A E" uniqKey="Pulver A" first="A. E." last="Pulver">A. E. Pulver</name></noRegion><name sortKey="Carpenter, B" sort="Carpenter, B" uniqKey="Carpenter B" first="B." last="Carpenter">B. Carpenter</name><name sortKey="Crowe, R R" sort="Crowe, R R" uniqKey="Crowe R" first="R. R." last="Crowe">R. R. Crowe</name><name sortKey="Duan, J" sort="Duan, J" uniqKey="Duan J" first="J." last="Duan">J. Duan</name><name sortKey="Gejman, P V" sort="Gejman, P V" uniqKey="Gejman P" first="P. V." last="Gejman">P. V. Gejman</name><name sortKey="Kendler, K S" sort="Kendler, K S" uniqKey="Kendler K" first="K. S." last="Kendler">K. S. Kendler</name><name sortKey="Levinson, D F" sort="Levinson, D F" uniqKey="Levinson D" first="D. F." last="Levinson">D. F. Levinson</name><name sortKey="Liang, K Y" sort="Liang, K Y" uniqKey="Liang K" first="K. Y." last="Liang">K. Y. Liang</name><name sortKey="Nestadt, G" sort="Nestadt, G" uniqKey="Nestadt G" first="G." last="Nestadt">G. Nestadt</name><name sortKey="Ribble, R" sort="Ribble, R" uniqKey="Ribble R" first="R." last="Ribble">R. Ribble</name><name sortKey="Riley, B" sort="Riley, B" uniqKey="Riley B" first="B." last="Riley">B. Riley</name><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><name sortKey="Sanders, A R" sort="Sanders, A R" uniqKey="Sanders A" first="A. R." last="Sanders">A. R. Sanders</name><name sortKey="Silverman, J M" sort="Silverman, J M" uniqKey="Silverman J" first="J. M." last="Silverman">J. M. Silverman</name><name sortKey="Wormley, B" sort="Wormley, B" uniqKey="Wormley B" first="B." last="Wormley">B. Wormley</name></country><country name="France"><region name="Île-de-France"><name sortKey="Laurent, C" sort="Laurent, C" uniqKey="Laurent C" first="C." last="Laurent">C. Laurent</name></region><name sortKey="Bauche, S" sort="Bauche, S" uniqKey="Bauche S" first="S." last="Bauche">S. Bauche</name><name sortKey="Deleuze, J F" sort="Deleuze, J F" uniqKey="Deleuze J" first="J.-F." last="Deleuze">J.-F. Deleuze</name><name sortKey="Jay, M" sort="Jay, M" uniqKey="Jay M" first="M." last="Jay">M. Jay</name><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name><name sortKey="Soubigou, S" sort="Soubigou, S" uniqKey="Soubigou S" first="S." last="Soubigou">S. Soubigou</name></country><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Schwab, S G" sort="Schwab, S G" uniqKey="Schwab S" first="S. G." last="Schwab">S. G. Schwab</name></region><name sortKey="Albus, M" sort="Albus, M" uniqKey="Albus M" first="M." last="Albus">M. Albus</name><name sortKey="Maier, W" sort="Maier, W" uniqKey="Maier W" first="W." last="Maier">W. Maier</name><name sortKey="Wildenauer, D B" sort="Wildenauer, D B" uniqKey="Wildenauer D" first="D. B." last="Wildenauer">D. B. Wildenauer</name></country><country name="Italie"><noRegion><name sortKey="Demarchi, N" sort="Demarchi, N" uniqKey="Demarchi N" first="N." last="Demarchi">N. Demarchi</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Walsh, D" sort="Walsh, D" uniqKey="Walsh D" first="D." last="Walsh">D. Walsh</name></noRegion></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Papadimitriou, G" sort="Papadimitriou, G" uniqKey="Papadimitriou G" first="G." last="Papadimitriou">G. Papadimitriou</name></region><name sortKey="Dikeos, D" sort="Dikeos, D" uniqKey="Dikeos D" first="D." last="Dikeos">D. Dikeos</name></country><country name="Israël"><noRegion><name sortKey="Lerer, F B" sort="Lerer, F B" uniqKey="Lerer F" first="F. B." last="Lerer">F. B. 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